2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
    Neuronal Signaling
  4. Calcium Channel

Calcium Channel

Ca2+ channels; Ca channels

Calcium Channel

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Calcium channel is an ion channel which displays selective permeability to calcium ions. It is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels. Voltage-gated calcium (CaV) channels catalyse rapid, highly selective influx of Ca2+ into cells despite a 70-fold higher extracellular concentration of Na+. Some calcium channel blockers have the added benefit of slowing your heart rate, which can further reduce blood pressure, relieve chest pain (angina) and control an irregular heartbeat.

Calcium Channel Isoform Specific Products:

Calcium Channel Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B0317C
    Amlodipine mesylate
    		Antagonist
    Amlodipine mesylate, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine mesylate can be used for the research of high blood pressure and cancer.
    Amlodipine mesylate
  • HY-15553B
    Mibefradil dihydrochloride hydrate
    		Antagonist
    Mibefradil dihydrochloride hydrate (Ro 40-5967 dihydrochloride hydrate) is a effectively long-acting calcium channel antagonist, used as an antihypertensive agent. Mibefradil dihydrochloride hydrate acts via a higher affinity block for low-voltage-activated (T) than for high-voltage-activated (L) calcium channels.
    Mibefradil dihydrochloride hydrate
  • HY-10341B
    Fasudil hydrochloride semihydrate
    		Antagonist
    Fasudil (HA-1077; AT877) hydrochloride semihydrate is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively. Fasudil hydrochloride semihydrate is also a potent Ca2+ channel antagonist and vasodilator.
    Fasudil hydrochloride semihydrate
  • HY-B0632S
    Diltiazem-d6
    		Antagonist
    Diltiazem-d6 is the deuterium labeled Diltiazem. Diltiazem is an orally active L-type Ca2+ channel blocker, with antihypertensive and antiarrhythmic effects. Diltiazem can be used for the research of cardiac arrhythmia, hypertension, and angina pectoris.
    Diltiazem-d<sub>6</sub>
  • HY-17436S1
    Clevidipine-d7
    		Antagonist
    Clevidipine-d7 is the deuterium labeled Clevidipine. Clevidipine is a short-acting dihydropyridine calcium channel antagonist (IC50= 7.1 nM, V(H) = -40 mV ) under development for treatment of perioperative hypertension.
    Clevidipine-d<sub>7</sub>
  • HY-W700354
    (S)-(-)-Felodipine
    		Antagonist
    (S)-(-)-Felodipine is a S-enantiomer of Felodipine. (S)-(-)-Felodipine is an antihypertensive agent. Felodipine is a 1,4-dihydropyridine derivative and a vasoselective calcium antagonist. Felodipine can prevent the activation of the vascular effector cells and interfere with the contractile process in vitro. Felodipine lowers mean arterial blood pressure by 20% in dog model. (S)-(-)-Felodipine shows high metabolic rate in rat and dog liver microsomes.
    (S)-(-)-Felodipine
  • HY-136644
    PD-217014-methyl ester
    		Antagonist
    PD-217014-methyl ester is an α?δ ligand with visceral analgesic activity and can inhibit visceral hypersensitivity, and its anti-hyperalgesic effect is dose-dependent.
    PD-217014-methyl ester
  • HY-115596
    BTT-369
    		Antagonist
    BTT-369 is a CaVα1·CaVβ3 protein-protein complex antagonist with a Ki of 2.0 μM. BTT-369 inhibits CaV2.2 currents, with an apparent IC50 value of 31 μM. BTT-369 disrupts the interaction between CaVα1 and CaVβ3 subunits. BTT-369 reduces the current density of CaV2.2, and shifts the voltage dependence of steady-state inactivation and activation of CaV2.2 to more positive potentials. BTT-369 alleviates mechanical hyperalgesia in a rat model of tibial nerve injury. BTT-369 can be used for the study of neuropathic pain.
    BTT-369
  • HY-N19667
    8-[2-(3-Methylbutroxy)-3-hydroxy-3-methylbutoxy]psoralen
    		Antagonist
    8-[2-(3-Methylbutroxy)-3-hydroxy-3-methylbutoxy]psoralen (Compound 12), a furanocoumarin found in the roots of A. archangelica L. archangelica, is an calcium antagonist. 8-[2-(3-Methylbutroxy)-3-hydroxy-3-methylbutoxy]psoralen blocks depolarization-induced calcium uptake in pituitary cells. 8-[2-(3-Methylbutroxy)-3-hydroxy-3-methylbutoxy]psoralen can be used for research on anti-inflammatory and analgesic activities.
    8-[2-(3-Methylbutroxy)-3-hydroxy-3-methylbutoxy]psoralen
  • HY-169845
    Calcium Channel antagonist 6
    		Antagonist
    Calcium Channel antagonist 6 (Compound 328) is a highly selective antagonist of voltage-gated calcium channel CaV2.2 with an IC50 value of 0.37 μM. Calcium Channel antagonist 6 inhibits of neuron depolarization-induced Ca2+ influx. Calcium Channel antagonist 6 is promising for research of neuropathic pain.
    Calcium Channel antagonist 6
  • HY-106904
    Nexopamil
    		Antagonist
    Nexopamil is a calcium antagonist of Ca2+ channel, 5HT2, 5HT1A, 5HT1C and dopamine D2 receptors. Nexopamil exhibits vasodilatory, cardioprotective, and platelet aggregation inhibiting effects. Nexopamil can be used for researches of stable or unstable angina and possibly of peripheral arterial occlusive disease.
    Nexopamil
  • HY-W278072
    Calcium Channel antagonist 1
    		Antagonist
    Calcium Channel antagonist 1 is an antagonist of Calcium Channel Calcium Channel antagonist 1 has the potential for the research of neurology disease.
    Calcium Channel antagonist 1
  • HY-16489
    Terodiline
    		Antagonist
    Terodiline, an antispasmodic agent, blocks hERG current with the IC50 of 375 nM. Terodiline has both anticholinergic and calcium antagonist properties, and effectively reduces abnormal bladder contractions caused by detrusor instability. Terodiline can be used for the research of urinary incontinence.
    Terodiline
  • HY-106832
    Vatanidipine
    		Antagonist
    Vatanidipine (Watanidipine) is an orally active dihydropyridine (DHP)-type calcium channel blocker and a useful antihypertensive agent. Vatanidipine shows vasodilatory effects and also suppresses noradrenaline release from sympathetic nerve endings.
    Vatanidipine
  • HY-137203
    (+)-Niguldipine
    		Antagonist
    (+)-Niguldipine is a potent dual inhibitor targeting L-type Ca2+ channels (Ki=85 pM) and α₁-adrenoceptor (Ki=52 pM). (+)-Niguldipine is promising for research of hypertension and cardiovascular diseases.
    (+)-Niguldipine
  • HY-N0215S13
    L-Phenylalanine-d
    		Antagonist 99.5%
    L-Phenylalanine-d is the deuterium labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals.
    L-Phenylalanine-d
  • HY-117099
    TMB-8
    		Antagonist 98.0%
    TMB-8 is a novel Ca 2+ antagonist. TMB-8 may exert inhibitory effects in smooth muscle by blocking Ca 2+ release from intracellular bound stores.
    TMB-8
  • HY-101390D
    (R)-Niguldipine
    		Antagonist
    (R)-Niguldipine, a R-epimer of Niguldipine (HY-101390B), is a calcium channel antagonist. (R)-Niguldipine exerts a vasodilatory effect by blocking calcium channels and reducing the transmembrane influx of calcium ions. (R)-Niguldipine can inhibit U-46619 (HY-108566)-induced coronary artery contraction in guinea pig Langendorff hearts (pID50 of 9.93), has high affinity for calcium channel binding sites on guinea pig skeletal muscle membranes (Ki of 8.10), and lowers blood pressure in spontaneously hypertensive rats (pED30 of 5.55). (R)-Niguldipine can improve cardiovascular diseases such as hypertension, angina pectoris, and arrhythmias.
    (R)-Niguldipine
  • HY-118674
    AK-2-38
    		Antagonist
    AK-2-38, a Nifedipine (HY-B0284) analogue, is a calcium channel antagonist. AK-2-38 also has partial agonist effects on isolated guinea pig left atrium.
    AK-2-38
  • HY-101607
    KT-362
    		Antagonist
    KT-362 is an intracellular calcium antagonist. KT-362 can inhibit NE-induced contractions and IP accumulation in vivo experiments.
    KT-362
Cat. No. Product Name / Synonyms Application Reactivity
Calcium Channel Isoform Comparison

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